The Impact of Some Modulators of the Renin–Angiotensin System on the Scopolamine-Induced Memory Loss Mice Model

As some of the renin–angiotensin–aldosterone system (RAAS)-dependent mechanisms underlying cognitive performance modulation could include oxidative balance alterations, in this study we aimed to describe potential interactions between RAAS modulators (Losartan and Ramipril) stress a typical model memory impairment. In study, 48 white male Swiss mice were divided into six groups received (oral administration Ramipril 4 mg/kg, Losartan 20 mg/kg) muscarinic receptors inhibitor (intraperitoneal injection scopolamine, 0.5 for 8 consecutive days. Then, 24 h after last administration, animals euthanized whole blood brain tissues collected. Biological samples then processed, biochemical analysis was carried out assess superoxide dismutase glutathione activities malondialdehyde concentrations. present experimental conditions, showed that via angiotensin-converting enzyme inhibition (Ramipril) angiotensin II receptor blockage (Losartan) chronic treatments lead non-selective blocker (scopolamine) animal model. Our results exhibit significant systemic antioxidant partly preventing negative effects scopolamine potential, mainly by inhibiting oxidative-stress-mediated cellular damage apoptosis. also minimize oxidative-mediated lipid components tissue resulting from administration. Both serum changes status observed following 8-day with Ramipril, Losartan, combinations. While suggest effect on circulatory system, vessels endothelia, arterial tension modulation, important information complex interaction renin–angiotensin cholinergic systems.